Several viewpoints and trailheads in the park have limited or no parking and must be reached using the park shuttle system. The National Park Service runs an extensive shuttle service on the South Rim [28] with three interlocking routes. The service is free, and generally runs from before sunrise until after sunset, depending on the route. Service is more frequent from May through September and includes additional routes. In addition, during the summer the park service operates a shuttle from Tusayan into the park.

Horse and mule riders are required to follow a number of rules and restrictions while in the park, and must get a permit from the park service to keep animals in the park overnight.

From Mar-Nov the West Rim Drive is not accessible to most private vehicles (handicap vehicles may request a variance at the entry gate). The park service runs a shuttle during this time. The shuttles are frequent but long lines form during the busy summer months.